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Finding the Genetic Link

While approximately

90% of ovarian cancers occur by chance,

10% of women with ovarian cancer

have inherited genetic changes

that predisposed them to the disease.

Research has successfully identified three hereditary factors that predispose women to ovarian cancer:
  • Spontaneous new mutations in the tumor suppressor genes BRCA1 and BRCA2
  • Susceptibility to HNPCC also known as Lynch Syndrome II—a hereditary disease that puts individuals at greater risk for colorectal cancer, and subsequent risk for ovarian cancer
  • Hereditary mutations in the BRCA1 gene or BRCA2 gene.